| Reaction Details |
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 | Report a problem with these data |
| Target | Neprilysin |
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| Ligand | BDBM50040405 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_144598 (CHEMBL747373) |
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| IC50 | 4±n/a nM |
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| Citation |  De Lombaert, S; Erion, MD; Tan, J; Blanchard, L; el-Chehabi, L; Ghai, RD; Sakane, Y; Berry, C; Trapani, AJ N-Phosphonomethyl dipeptides and their phosphonate prodrugs, a new generation of neutral endopeptidase (NEP, EC 3.4.24.11) inhibitors. J Med Chem37:498-511 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Neprilysin |
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| Name: | Neprilysin |
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| Synonyms: | Mme | NEP_RAT | Neprilysin | Neutral Endopeptidase (NEP) | Neutral endopeptidase 24.11 |
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| Type: | Protein |
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| Mol. Mass.: | 85789.59 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P07861 |
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| Residue: | 750 |
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| Sequence: | MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDASAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKD
VLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLTLLPDIYGWPVASQNWEQTYGT
SWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEQRLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLY
NKMTLAKLQNNFSLEINGKPFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILT
KYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERI
GYPDDIISNENKLNNEYLELNYKEEEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSARQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLGENIADNGGIGQAYR
AYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFADAFHCRKNSYMNPERKCRVW
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| BDBM50040405 |
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| n/a |
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| Name | BDBM50040405 |
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| Synonyms: | 3-[3-Biphenyl-4-yl-2-(phosphonomethyl-amino)-propionylamino]-propionic acid | CHEMBL148521 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H23N2O6P |
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| Mol. Mass. | 406.3695 |
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| SMILES | OC(=O)CCNC(=O)C(Cc1ccc(cc1)-c1ccccc1)NCP(O)(O)=O |
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| Structure | 
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