Reaction Details |
| Report a problem with these data |
Target | Bifunctional dihydrofolate reductase-thymidylate synthase |
---|
Ligand | BDBM50036491 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_53464 (CHEMBL665589) |
---|
IC50 | 5900±n/a nM |
---|
Citation | Rosowsky, A; Mota, CE; Queener, SF; Waltham, M; Ercikan-Abali, E; Bertino, JR 2,4-Diamino-5-substituted-quinazolines as inhibitors of a human dihydrofolate reductase with a site-directed mutation at position 22 and of the dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii. J Med Chem38:745-52 (1995) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Bifunctional dihydrofolate reductase-thymidylate synthase |
---|
Name: | Bifunctional dihydrofolate reductase-thymidylate synthase |
Synonyms: | DHFR-TS | DRTS_TOXGO | Dihydrofolate reductase | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; T. gondii vs rat |
Type: | Enzyme |
Mol. Mass.: | 68757.49 |
Organism: | Toxoplasma gondii |
Description: | Q07422 |
Residue: | 610 |
Sequence: | MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKT
GDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEG
QQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPC
DVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNG
VPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEE
DRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYS
LDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHR
EVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAA
LDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKP
KEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVP
HGRIQMEMAV
|
|
|
BDBM50036491 |
---|
n/a |
---|
Name | BDBM50036491 |
Synonyms: | 5-[2-(2,5-Dimethoxy-phenyl)-ethyl]-quinazoline-2,4-diamine | CHEMBL349149 |
Type | Small organic molecule |
Emp. Form. | C18H20N4O2 |
Mol. Mass. | 324.377 |
SMILES | COc1ccc(OC)c(CCc2cccc3nc(N)nc(N)c23)c1 |
Structure |
|