| Reaction Details |
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 | Report a problem with these data |
| Target | D(2) dopamine receptor |
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| Ligand | BDBM50034057 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_58535 (CHEMBL669082) |
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| IC50 | 969±n/a nM |
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| Citation |  Strupczewski, JT; Bordeau, KJ; Chiang, Y; Glamkowski, EJ; Conway, PG; Corbett, R; Hartman, HB; Szewczak, MR; Wilmot, CA; Helsley, GC 3-[[(Aryloxy)alkyl]piperidinyl]-1,2-benzisoxazoles as D2/5-HT2 antagonists with potential atypical antipsychotic activity: antipsychotic profile of iloperidone (HP 873). J Med Chem38:1119-31 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| D(2) dopamine receptor |
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| Name: | D(2) dopamine receptor |
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| Synonyms: | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 50931.60 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P61169 |
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| Residue: | 444 |
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| Sequence: | MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMS
RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS
AVNPIIYTTFNIEFRKAFMKILHC
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| BDBM50034057 |
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| n/a |
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| Name | BDBM50034057 |
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| Synonyms: | 1-{4-[2-(4-Benzo[d]isoxazol-3-yl-piperidin-1-yl)-ethoxy]-3-methoxy-phenyl}-ethanone | CHEMBL274462 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H26N2O4 |
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| Mol. Mass. | 394.4635 |
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| SMILES | COc1cc(ccc1OCCN1CCC(CC1)c1noc2ccccc12)C(C)=O |
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| Structure | 
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