| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine deaminase |
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| Ligand | BDBM50407749 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_30974 (CHEMBL646136) |
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| Ki | 0.002500±n/a nM |
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| Citation |  Marrone, TJ; Straatsma, TP; Briggs, JM; Wilson, DK; Quiocho, FA; McCammon, JA Theoretical study of inhibition of adenosine deaminase by (8R)-coformycin and (8R)-deoxycoformycin. J Med Chem39:277-84 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine deaminase |
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| Name: | Adenosine deaminase |
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| Synonyms: | ADA | ADA1 | ADA_HUMAN | Adenosine aminohydrolase |
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| Type: | Enzyme |
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| Mol. Mass.: | 40759.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant ADA was expressed and purified from an ADA-deficient bacterial strain. |
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| Residue: | 363 |
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| Sequence: | MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPD
FLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQA
EGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAI
DLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGY
HTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIF
KSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAG
QNL
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| BDBM50407749 |
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| n/a |
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| Name | BDBM50407749 |
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| Synonyms: | CHEMBL2112110 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H17N3O4 |
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| Mol. Mass. | 267.2811 |
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| SMILES | OC[C@@H]1O[C@@H](C[C@H]1O)n1cnc2[C@H](O)CCC=Nc12 |c:17| |
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| Structure | 
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