Ki Summary

Reaction Details

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Target

Transporter

Ligand

BDBM50035738

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_142948 (CHEMBL750800)

IC50

60.1±n/a nM

Citation

Holmquist, CR; Keverline-Frantz, KI; Abraham, P; Boja, JW; Kuhar, MJ; Carroll, FI 3 alpha-(4'-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters: novel ligands with high affinity and selectivity at the dopamine transporter. J Med Chem39:4139-41 (1996) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Transporter

Name:

Transporter

Synonyms:

Monoamine transporters; Norepininephrine & dopamine | Norepinephrine Monoamine transporters

Type:

PROTEIN

Mol. Mass.:

66787.87

Organism:

Rattus norvegicus

Description:

ChEMBL_1463061

Residue:

597

Sequence:

MVTRTRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLF
YMELALGQFNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLN
LPWTNCGHAWNSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDI
GLPQWQLLLCLMVVIVVLYVSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNG
INAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTIN
CVTSFISGFAIFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFL
MLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLT
LLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLL
FVVVVSIINFKPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAY
GITPENEHHLLALEIELSSLQSFVITSCPIDPLLSSFLFISCQKTLVFKKSGPAPLI

BDBM50035738

n/a

Name

BDBM50035738

Synonyms:

(R)-3-(4-Chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester | 3-(4-Chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester | 3-(4-Fluoro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester | CHEMBL306208

Type

Small organic molecule

Emp. Form.

C16H20ClNO2

Mol. Mass.

293.789

SMILES

COC(=O)C1C2CCC(CC1c1ccc(Cl)cc1)N2C |TLB:11:10:18:6.7,THB:2:4:18:6.7|

Structure