| Reaction Details |
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 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member B1 [K65Q] |
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| Ligand | BDBM16314 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_32263 (CHEMBL645597) |
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| IC50 | 96±n/a nM |
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| Citation |  Costantino, L; Rastelli, G; Vescovini, K; Cignarella, G; Vianello, P; Del Corso, A; Cappiello, M; Mura, U; Barlocco, D Synthesis, activity, and molecular modeling of a new series of tricyclic pyridazinones as selective aldose reductase inhibitors. J Med Chem39:4396-405 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldo-keto reductase family 1 member B1 [K65Q] |
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| Name: | Aldo-keto reductase family 1 member B1 [K65Q] |
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| Synonyms: | AKR1B1 | ALDR_BOVIN | Aldose reductase |
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| Type: | Protein |
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| Mol. Mass.: | 35916.27 |
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| Organism: | Bos taurus (Cattle) |
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| Description: | P16116[K65Q] |
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| Residue: | 315 |
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| Sequence: | AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQA
KLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKD
FFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPA
VNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKY
NKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACAL
VSCASHRDYPFHEEF
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| BDBM16314 |
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| n/a |
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| Name | BDBM16314 |
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| Synonyms: | 2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-N-methylmethanethioamido}acetic acid | Alredase | CHEMBL436 | N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]carbonothioyl}-N-methylglycine | Tolrestat |
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| Type | Small organic molecule |
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| Emp. Form. | C16H14F3NO3S |
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| Mol. Mass. | 357.347 |
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| SMILES | COc1ccc2c(cccc2c1C(F)(F)F)C(=S)N(C)CC(O)=O |
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| Structure | 
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