| Reaction Details |
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 | Report a problem with these data |
| Target | Type-2 angiotensin II receptor |
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| Ligand | BDBM50049206 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_35421 (CHEMBL643595) |
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| IC50 | 0.69±n/a nM |
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| Citation |  Wexler, RR; Greenlee, WJ; Irvin, JD; Goldberg, MR; Prendergast, K; Smith, RD; Timmermans, PB Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy. J Med Chem39:625-56 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Type-2 angiotensin II receptor |
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| Name: | Type-2 angiotensin II receptor |
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| Synonyms: | AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 41201.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Angiotensin II, central 0 0::P50052 |
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| Residue: | 363 |
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| Sequence: | MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFL
VNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVF
GSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFY
FRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLK
TNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLAL
PFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMET
FVS
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| BDBM50049206 |
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| n/a |
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| Name | BDBM50049206 |
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| Synonyms: | 5-Ethyl-3-(3-fluoro-2'-isopentyloxycarbaronylsulfamoyl-biphenyl-4-ylmethyl)-2-propyl3H-imidazole-4-carboxylicacid2-benzoyl-benzyl ester(EXP597) | Biphenylsulfonylcarbamate compound | CHEMBL74573 |
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| Type | Small organic molecule |
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| Emp. Form. | C42H44FN3O7S |
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| Mol. Mass. | 753.878 |
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| SMILES | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C |
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| Structure | 
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