| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium/potassium-transporting ATPase subunit alpha-1 |
|---|
| Ligand | BDBM46356 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_54059 (CHEMBL669632) |
|---|
| IC50 | 8±n/a nM |
|---|
| Citation |  Templeton, JF; Ling, Y; Marat, K; LaBella, FS Synthesis and structure-activity relationships of 17beta-substituted 14beta-hydroxysteroid 3-(alpha-L-rhamnopyranoside)s: steroids that bind to the digitalis receptor. J Med Chem40:1439-46 (1997) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium/potassium-transporting ATPase subunit alpha-1 |
|---|
| Name: | Sodium/potassium-transporting ATPase subunit alpha-1 |
|---|
| Synonyms: | AT1A1_CANLF | ATP1A1 | Sodium/potassium-transporting ATPase alpha-1 chain |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 112656.60 |
|---|
| Organism: | Canis familiaris |
|---|
| Description: | ChEMBL_144092 |
|---|
| Residue: | 1021 |
|---|
| Sequence: | MGKGVGRDKYEPAAVSEHGDKKKAKKERDMDELKKEVSMDDHKLSLDELHRKYGTDLSRG
LTTARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIGAILCFLAYGIQAATE
EEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINA
EEVVIGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNI
AFFSTNCVKGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFL
GVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLE
AVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKSSATWLALS
RIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRDRYAKIVEIPF
NSTNKYQLSIHKNPNTSEPRHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDALQNAY
LELGGLGERVLGFRHLFLPDEQFPEGFQFDTDDVNFPVENLCFVGFISMIGPPRAAVPDA
VGKCRGAGIKVIMVTGDHPITAKAIAKGAGIISEGNETVEDIAARLNIPVRQVNPRDAKA
CVVHGSDLKDMTSEQLDGILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDS
PALKKADIGVAMGIVGSDASKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTS
NIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTD
KLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPTHLLGLRVDWDDRWINDVEDSY
GQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEET
ALAAFLSYCPGMGVALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKETY
Y
|
|
|
|---|
| BDBM46356 |
|---|
| n/a |
|---|
| Name | BDBM46356 |
|---|
| Synonyms: | DIGITOXIN | MLS000069787 | SMR000058529 | US10668094, Compound Digitoxin | cid_441207 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C41H64O13 |
|---|
| Mol. Mass. | 764.9391 |
|---|
| SMILES | C[C@H]1O[C@H](C[C@H](O)[C@@H]1O)O[C@H]1[C@@H](O)C[C@H](O[C@H]2[C@@H](O)C[C@H](O[C@H]3CC[C@@]4(C)[C@H](CC[C@@H]5[C@@H]4CC[C@]4(C)[C@H](CC[C@]54O)C4=CC(=O)OC4)C3)O[C@@H]2C)O[C@@H]1C |t:45| |
|---|
| Structure | 
|
|---|
Search and Browse
