Reaction Details |
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Target | 5-hydroxytryptamine receptor 1A |
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Ligand | BDBM50054397 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1202 (CHEMBL615968) |
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Ki | 5970±n/a nM |
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Citation | López-Rodríguez, ML; Rosado, ML; Benhamú, B; Morcillo, MJ; Fernández, E; Schaper, KJ Synthesis and structure-activity relationships of a new model of arylpiperazines. 2. Three-dimensional quantitative structure-activity relationships of hydantoin-phenylpiperazine derivatives with affinity for 5-HT1A and alpha 1 receptors. A comparison of CoMFA models. J Med Chem40:1648-56 (1997) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 1A |
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Name: | 5-hydroxytryptamine receptor 1A |
Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46445.29 |
Organism: | Rattus norvegicus (rat) |
Description: | Binding assays were performed using rat hippocampal membranes. |
Residue: | 422 |
Sequence: | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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BDBM50054397 |
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n/a |
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Name | BDBM50054397 |
Synonyms: | 2-[4-(4-Nitro-phenyl)-piperazin-1-ylmethyl]-tetrahydro-imidazo[1,5-a]pyridine-1,3-dione | CHEMBL46862 |
Type | Small organic molecule |
Emp. Form. | C18H23N5O4 |
Mol. Mass. | 373.4063 |
SMILES | Oc1c2CCCCn2c(=O)n1CN1CCN(CC1)c1ccc(cc1)[N+]([O-])=O |
Structure |
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