Reaction Details |
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Target | Neutrophil elastase |
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Ligand | BDBM50058355 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_63997 (CHEMBL673106) |
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Ki | 6.1±n/a nM |
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Citation | Edwards, PD; Andisik, DW; Bryant, CA; Ewing, B; Gomes, B; Lewis, JJ; Rakiewicz, D; Steelman, G; Strimpler, A; Trainor, DA; Tuthill, PA; Mauger, RC; Veale, CA; Wildonger, RA; Williams, JC; Wolanin, DJ; Zottola, M Discovery and biological activity of orally active peptidyl trifluoromethyl ketone inhibitors of human neutrophil elastase. J Med Chem40:1876-85 (1997) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Neutrophil elastase |
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Name: | Neutrophil elastase |
Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
Type: | Enzyme |
Mol. Mass.: | 28532.38 |
Organism: | Homo sapiens (Human) |
Description: | P08246 |
Residue: | 267 |
Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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BDBM50058355 |
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n/a |
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Name | BDBM50058355 |
Synonyms: | 1-{(S)-3-Methyl-2-[4-(naphthalene-1-sulfonylamino)-4-oxo-butyrylamino]-butyryl}-pyrrolidine-2-carboxylic acid (3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-amide | CHEMBL291309 |
Type | Small organic molecule |
Emp. Form. | C30H37F3N4O7S |
Mol. Mass. | 654.698 |
SMILES | CC(C)[C@H](NC(=O)CCC(=O)NS(=O)(=O)c1cccc2ccccc12)C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)C(F)(F)F |
Structure |
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