Ki Summary

Reaction Details

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Target

Translocator protein

Ligand

BDBM50059739

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_37218 (CHEMBL651678)

IC50

3.4±n/a nM

Citation

Cappelli, A; Anzini, M; Vomero, S; De Benedetti, PG; Menziani, MC; Giorgi, G; Manzoni, C Mapping the peripheral benzodiazepine receptor binding site by conformationally restrained derivatives of 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3- isoquinolinecarboxamide (PK11195). J Med Chem40:2910-21 (1997) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Translocator protein

Name:

Translocator protein

Synonyms:

Type:

Mitochondrion membrane protein

Mol. Mass.:

18945.84

Organism:

Rattus norvegicus (rat)

Description:

Competitive binding experiments were performed on rat kidney mitochondrial membranes.

Residue:

169

Sequence:

MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE

BDBM50059739

n/a

Name

BDBM50059739

Synonyms:

4-(2-Fluoro-phenyl)-3-methyl-quinoline-2-carboxylic acid (4-chloro-benzyl)-methyl-amide | CHEMBL15254

Type

Small organic molecule

Emp. Form.

C25H20ClFN2O

Mol. Mass.

418.891

SMILES

CN(Cc1ccc(Cl)cc1)C(=O)c1nc2ccccc2c(c1C)-c1ccccc1F |(2.64,-12.53,;2.62,-10.99,;3.95,-10.2,;5.3,-10.97,;6.61,-10.18,;7.94,-10.94,;7.96,-12.49,;9.29,-13.25,;6.63,-13.26,;5.3,-12.51,;1.29,-10.23,;1.27,-8.69,;-.04,-11.01,;-1.38,-10.25,;-2.7,-11.02,;-4.04,-10.25,;-5.37,-11.04,;-5.37,-12.58,;-4.04,-13.35,;-2.7,-12.56,;-1.37,-13.33,;-.02,-12.55,;1.31,-13.31,;-1.37,-14.87,;-2.7,-15.64,;-2.7,-17.18,;-1.37,-17.95,;-.02,-17.16,;-.04,-15.63,;1.29,-14.86,)|

Structure