Ki Summary

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Target

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B

Ligand

BDBM50061066

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_161939 (CHEMBL769193)

IC50

0.20±n/a nM

Citation

Gupta, V; Ogawa, AK; Du, X; Houk, KN; Armstrong, RW A model for binding of structurally diverse natural product inhibitors of protein phosphatases PP1 and PP2A. J Med Chem40:3199-206 (1997) [PubMed] Article

More Info.:

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Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B

Name:

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B

Synonyms:

Serine-threonine protein phosphatase 2A regulatory subunit

Type:

PROTEIN

Mol. Mass.:

49694.81

Organism:

Gallus gallus

Description:

ChEMBL_161937

Residue:

426

Sequence:

DDDVAEADIISTVEFNHCGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHE
PEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDG
RYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSADDLRIN
LWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASAL
CDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPVE
TYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEA
SRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKILHHAWHPKENIIAVATTNNLYI
FQDKMN

BDBM50061066

n/a

Name

BDBM50061066

Synonyms:

(5R,6S,9S,12S,13S,16R)-2-Eth-(Z)-ylidene-9-(3-guanidino-propyl)-12-((1E,3E)-(5S,6S)-6-methoxy-3,5-dimethyl-7-phenyl-hepta-1,3-dienyl)-1,6,13-trimethyl-3,7,10,14,19-pentaoxo-1,4,8,11,15pentaaza-cyclononadecane-5,16-dicarboxylic acid | CHEMBL108308

Type

Small organic molecule

Emp. Form.

C41H60N8O10

Mol. Mass.

824.9627

SMILES

CO[C@@H](Cc1ccccc1)[C@@H](C)\C=C(/C)\C=C\[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](C)[C@@H](NC(=O)\C(=C\C)N(C)C(=O)CC[C@@H](NC(=O)[C@H]1C)C(O)=O)C(O)=O

Structure