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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 5-hydroxytryptamine receptor 3A/3B | ||
| Ligand | BDBM50060267 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2997 (CHEMBL872925) | ||
| Ki | 98±n/a nM | ||
| Citation |  Heidempergher, F; Pillan, A; Pinciroli, V; Vaghi, F; Arrigoni, C; Bolis, G; Caccia, C; Dho, L; McArthur, R; Varasi, M Phenylimidazolidin-2-one derivatives as selective 5-HT3 receptor antagonists and refinement of the pharmacophore model for 5-HT3 receptor binding. J Med Chem40:3369-80 (1997) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 5-hydroxytryptamine receptor 3A/3B | |||
| Name: | 5-hydroxytryptamine receptor 3A/3B | ||
| Synonyms: | Serotonin 3 (5-HT3) receptor | Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor | ||
| Type: | n/a | ||
| Mol. Mass.: | n/a | ||
| Description: | ASSAY_ID of EBI is 2974 | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | 5-hydroxytryptamine receptor 3B | ||
| Synonyms: | 5HT3B_RAT | Htr3b | Serotonin (5-HT) receptor | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 50328.78 | ||
| Organism: | Rattus norvegicus | ||
| Description: | EBI_11885 | ||
| Residue: | 437 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | 5-hydroxytryptamine receptor 3A | ||
| Synonyms: | 5-HT3 | 5-hydroxytryptamine receptor 3A | 5HT3A_RAT | 5ht3 | Htr3 | Htr3a | Serotonin (5-HT) receptor | Zacopride site-R | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 55428.70 | ||
| Organism: | RAT | ||
| Description: | 5-HT3 HTR3A RAT::P35563 | ||
| Residue: | 483 | ||
| Sequence: |
| ||
| BDBM50060267 | |||
| n/a | |||
| Name | BDBM50060267 | ||
| Synonyms: | 1-(1-Aza-bicyclo[2.2.2]oct-3-yl)-3-(3-trifluoromethyl-phenyl)-imidazolidin-2-one | CHEMBL114921 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H20F3N3O | ||
| Mol. Mass. | 339.3554 | ||
| SMILES | FC(F)(F)c1cccc(c1)N1CCN(C2CN3CCC2CC3)C1=O |THB:13:14:18.17:20.21,(-1.17,-14.36,;.04,-15.05,;-.21,-13.46,;-1.46,-15.63,;1.38,-15.82,;1.38,-17.37,;2.7,-18.14,;4.04,-17.37,;4.04,-15.82,;2.7,-15.05,;5.36,-15.03,;6.76,-15.66,;7.78,-14.52,;7.01,-13.17,;7.62,-11.77,;7.85,-10.36,;9.11,-8.98,;8.66,-7.99,;8.24,-9.07,;8.79,-10.32,;10.61,-10.57,;10.9,-9.2,;5.51,-13.52,;4.36,-12.49,)| | ||
| Structure | 
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