| Reaction Details |
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 | Report a problem with these data |
| Target | Acetylcholine receptor subunit alpha/beta/delta/gamma |
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| Ligand | BDBM50061562 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_216979 (CHEMBL822796) |
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| Ki | 314±n/a nM |
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| Citation |  Holladay, MW; Dart, MJ; Lynch, JK Neuronal nicotinic acetylcholine receptors as targets for drug discovery. J Med Chem40:4169-94 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acetylcholine receptor subunit alpha/beta/delta/gamma |
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| Name: | Acetylcholine receptor subunit alpha/beta/delta/gamma |
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| Synonyms: | Acetylcholine receptor | Acetylcholine receptor protein alpha/beta/delta/gamma chain |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of EBI is 143080 |
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| Components: | This complex has 4 components. |
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| Component 1 |
| Name: | Acetylcholine receptor subunit beta |
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| Synonyms: | ACHB_TETCF | Acetylcholine receptor | CHRNB1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56146.98 |
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| Organism: | Torpedo californica |
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| Description: | EBI_19626 |
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| Residue: | 493 |
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| Sequence: | MENVRRMALGLVVMMALALSGVGASVMEDTLLSVLFETYNPKVRPAQTVGDKVTVRVGLT
LTNLLILNEKIEEMTTNVFLNLAWTDYRLQWDPAAYEGIKDLRIPSSDVWQPDIVLMNNN
DGSFEITLHVNVLVQHTGAVSWQPSAIYRSSCTIKVMYFPFDWQNCTMVFKSYTYDTSEV
TLQHALDAKGEREVKEIVINKDAFTENGQWSIEHKPSRKNWRSDDPSYEDVTFYLIIQRK
PLFYIVYTIIPCILISILAILVFYLPPDAGEKMSLSISALLAVTVFLLLLADKVPETSLS
VPIIIRYLMFIMILVAFSVILSVVVLNLHHRSPNTHTMPNWIRQIFIETLPPFLWIQRPV
TTPSPDSKPTIISRANDEYFIRKPAGDFVCPVDNARVAVQPERLFSEMKWHLNGLTQPVT
LPQDLKEAVEAIKYIAEQLESASEFDDLKKDWQYVAMVADRLFLYVFFVICSIGTFSIFL
DASHNVPPDNPFA
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| Component 2 |
| Name: | Acetylcholine receptor subunit gamma |
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| Synonyms: | ACHG_TETCF | Acetylcholine receptor | CHRNG |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58151.68 |
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| Organism: | Torpedo californica |
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| Description: | EBI_19662 |
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| Residue: | 506 |
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| Sequence: | MVLTLLLIICLALEVRSENEEGRLIEKLLGDYDKRIIPAKTLDHIIDVTLKLTLTNLISL
NEKEEALTTNVWIEIQWNDYRLSWNTSEYEGIDLVRIPSELLWLPDVVLENNVDGQFEVA
YYANVLVYNDGSMYWLPPAIYRSTCPIAVTYFPFDWQNCSLVFRSQTYNAHEVNLQLSAE
EGEAVEWIHIDPEDFTENGEWTIRHRPAKKNYNWQLTKDDTDFQEIIFFLIIQRKPLFYI
INIIAPCVLISSLVVLVYFLPAQAGGQKCTLSISVLLAQTIFLFLIAQKVPETSLNVPLI
GKYLIFVMFVSMLIVMNCVIVLNVSLRTPNTHSLSEKIKHLFLGFLPKYLGMQLEPSEET
PEKPQPRRRSSFGIMIKAEEYILKKPRSELMFEEQKDRHGLKRVNKMTSDIDIGTTVDLY
KDLANFAPEIKSCVEACNFIAKSTKEQNDSGSENENWVLIGKVIDKACFWIALLLFSIGT
LAIFLTGHFNQVPEFPFPGDPRKYVP
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| Component 3 |
| Name: | Acetylcholine receptor subunit alpha |
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| Synonyms: | ACHA_TETCF | Acetylcholine receptor | Acetylcholine receptor protein alpha chain | CHRNA1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52735.09 |
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| Organism: | Torpedo californica |
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| Description: | ChEMBL_216981 |
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| Residue: | 461 |
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| Sequence: | MILCSYWHVGLVLLLFSCCGLVLGSEHETRLVANLLENYNKVIRPVEHHTHFVDITVGLQ
LIQLISVDEVNQIVETNVRLRQQWIDVRLRWNPADYGGIKKIRLPSDDVWLPDLVLYNNA
DGDFAIVHMTKLLLDYTGKIMWTPPAIFKSYCEIIVTHFPFDQQNCTMKLGIWTYDGTKV
SISPESDRPDLSTFMESGEWVMKDYRGWKHWVYYTCCPDTPYLDITYHFIMQRIPLYFVV
NVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGK
YMLFTMIFVISSIIITVVVINTHHRSPSTHTMPQWVRKIFIDTIPNVMFFSTMKRASKEK
QENKIFADDIDISDISGKQVTGEVIFQTPLIKNPDVKSAIEGVKYIAEHMKSDEESSNAA
EEWKYVAMVIDHILLCVFMLICIIGTVSVFAGRLIELSQEG
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| Component 4 |
| Name: | Acetylcholine receptor subunit delta |
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| Synonyms: | ACHD_TETCF | Acetylcholine receptor | Acetylcholine receptor protein delta chain | chrnd |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59885.01 |
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| Organism: | Torpedo californica |
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| Description: | ChEMBL_142744 |
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| Residue: | 522 |
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| Sequence: | MGNIHFVYLLISCLYYSGCSGVNEEERLINDLLIVNKYNKHVRPVKHNNEVVNIALSLTL
SNLISLKETDETLTSNVWMDHAWYDHRLTWNASEYSDISILRLPPELVWIPDIVLQNNND
GQYHVAYFCNVLVRPNGYVTWLPPAIFRSSCPINVLYFPFDWQNCSLKFTALNYDANEIT
MDLMTDTIDGKDYPIEWIIIDPEAFTENGEWEIIHKPAKKNIYPDKFPNGTNYQDVTFYL
IIRRKPLFYVINFITPCVLISFLASLAFYLPAESGEKMSTAISVLLAQAVFLLLTSQRLP
ETALAVPLIGKYLMFIMSLVTGVIVNCGIVLNFHFRTPSTHVLSTRVKQIFLEKLPRILH
MSRADESEQPDWQNDLKLRRSSSVGYISKAQEYFNIKSRSELMFEKQSERHGLVPRVTPR
IGFGNNNENIAASDQLHDEIKSGIDSTNYIVKQIKEKNAYDEEVGNWNLVGQTIDRLSMF
IITPVMVLGTIFIFVMGNFNHPPAKPFEGDPFDYSSDHPRCA
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| BDBM50061562 |
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| n/a |
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| Name | BDBM50061562 |
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| Synonyms: | (12R,13aR)-12-Methoxy-1,4,5,6,9,11,12,13-octahydro-8H-pyrano[4',3':3,4]pyrido[2,1-i]indol-2-one | CHEMBL335712 | Dihydro-Beta-erythroidine |
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| Type | Small organic molecule |
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| Emp. Form. | C16H21NO3 |
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| Mol. Mass. | 275.3428 |
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| SMILES | CO[C@@H]1CC=C2CCN3CCC4=C(CC(=O)OC4)[C@@]23C1 |t:4,11| |
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| Structure | 
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