| Reaction Details |
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 | Report a problem with these data |
| Target | D(3) dopamine receptor |
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| Ligand | BDBM50061642 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_62126 (CHEMBL673447) |
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| Ki | 1.1±n/a nM |
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| Citation |  Mewshaw, RE; Kavanagh, J; Stack, G; Marquis, KL; Shi, X; Kagan, MZ; Webb, MB; Katz, AH; Park, A; Kang, YH; Abou-Gharbia, M; Scerni, R; Wasik, T; Cortes-Burgos, L; Spangler, T; Brennan, JA; Piesla, M; Mazandarani, H; Cockett, MI; Ochalski, R; Coupet, J; Andree, TH New generation dopaminergic agents. 1. Discovery of a novel scaffold which embraces the D2 agonist pharmacophore. Structure-activity relationships of a series of 2-(aminomethyl)chromans. J Med Chem40:4235-56 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| D(3) dopamine receptor |
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| Name: | D(3) dopamine receptor |
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| Synonyms: | DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3 |
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| Type: | n/a |
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| Mol. Mass.: | 44243.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 400 |
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| Sequence: | MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK
LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
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| BDBM50061642 |
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| n/a |
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| Name | BDBM50061642 |
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| Synonyms: | (S)-3-(Benzylamino-methyl)-2,3-dihydro-benzo[1,4]dioxin-6-ol; oxalic acid | CHEMBL300571 | CHEMBL423890 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H17NO3 |
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| Mol. Mass. | 271.3111 |
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| SMILES | Oc1ccc2OC[C@H](CNCc3ccccc3)Oc2c1 |
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| Structure | 
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