Ki Summary

Reaction Details

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Target

5-hydroxytryptamine receptor 4

Ligand

BDBM50056402

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_3340 (CHEMBL619040)

5.5±n/a nM

Citation

Yang, D; Soulier, JL; Sicsic, S; Mathé-Allainmat, M; Brémont, B; Croci, T; Cardamone, R; Aureggi, G; Langlois, M New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors. J Med Chem40:608-21 (1997) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 4

Name:

5-hydroxytryptamine receptor 4

Synonyms:

5-HT-4 | 5-HT4 | 5-HT4L | 5-HT4S | 5-hydroxytryptamine receptor 4 | 5HT4R_RAT | Htr4 | Serotonin (5-HT) receptor | Serotonin 4 (5-HT4) receptor

Type:

Enzyme Catalytic Domain

Mol. Mass.:

46117.31

Organism:

RAT

Description:

5-HT4 HTR4 RAT::Q62758

Residue:

406

Sequence:

MDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIV
SLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYY
AICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSN
STFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRP
QTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWL
GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRD
TVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS

BDBM50056402

n/a

Name

BDBM50056402

Synonyms:

4-Amino-5-chloro-2-methoxy-benzoic acid 2-(3-aza-bicyclo[3.2.2]non-3-yl)-ethyl ester | CHEMBL158147

Type

Small organic molecule

Emp. Form.

C18H25ClN2O3

Mol. Mass.

352.856

SMILES

COc1cc(N)c(Cl)cc1C(=O)OCCN1CC2CCC(CC2)C1 |TLB:14:15:21.22:18.19,(7.65,-14.52,;7.65,-12.98,;6.3,-12.21,;4.96,-12.98,;3.63,-12.21,;2.29,-12.98,;3.63,-10.66,;2.3,-9.89,;4.96,-9.87,;6.3,-10.65,;7.63,-9.87,;7.63,-8.33,;8.98,-10.64,;10.31,-9.87,;11.65,-10.62,;12.98,-9.85,;15.15,-9.38,;15.16,-10.46,;13.44,-11.25,;12.67,-12.46,;14.32,-11.58,;15.91,-12.53,;16.7,-11.39,;14.32,-10.2,)|

Structure