| Reaction Details |
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 | Report a problem with these data |
| Target | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 |
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| Ligand | BDBM50031877 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_329 (CHEMBL615302) |
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| Ki | 1600±n/a nM |
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| Citation |  Kenny, B; Ballard, S; Blagg, J; Fox, D Pharmacological options in the treatment of benign prostatic hyperplasia. J Med Chem40:1293-315 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 |
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| Name: | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 |
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| Synonyms: | 3-beta-HSD I | 3-beta-hydroxy-5-ene steroid dehydrogenase | 3-beta-hydroxy-Delta(5)-steroid dehydrogenase | 3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I | 3BH | 3BHS1_HUMAN | Delta-5-3-ketosteroid isomerase | HSD3B1 | HSDB3A | Progesterone reductase | Trophoblast antigen FDO161G |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42261.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_241 |
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| Residue: | 373 |
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| Sequence: | MTGWSCLVTGAGGFLGQRIIRLLVKEKELKEIRVLDKAFGPELREEFSKLQNKTKLTVLE
GDILDEPFLKRACQDVSVIIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPVF
IYTSSIEVAGPNSYKEIIQNGHEEEPLENTWPAPYPHSKKLAEKAVLAANGWNLKNGGTL
YTCALRPMYIYGEGSRFLSASINEALNNNGILSSVGKFSTVNPVYVGNVAWAHILALRAL
QDPKKAPSIRGQFYYISDDTPHQSYDNLNYTLSKEFGLRLDSRWSFPLSLMYWIGFLLEI
VSFLLRPIYTYRPPFNRHIVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQKTVEWVGSL
VDRHKETLKSKTQ
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| BDBM50031877 |
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| n/a |
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| Name | BDBM50031877 |
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| Synonyms: | (1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid (2-tert-butyl-5-trifluoromethyl-phenyl)-amide | CHEMBL277224 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H39F3N2O2 |
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| Mol. Mass. | 516.6381 |
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| SMILES | CC(C)(C)c1ccc(cc1NC(=O)[C@H]1CCC2C3CN=C4CC(=O)CC[C@]4(C)C3CC[C@]12C)C(F)(F)F |t:20| |
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| Structure | 
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