Reaction Details |
| Report a problem with these data |
Target | Histamine H1 receptor |
---|
Ligand | BDBM50040253 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_83926 (CHEMBL693691) |
---|
Ki | 685±n/a nM |
---|
Citation | Chern, JW; Tao, PL; Wang, KC; Gutcait, A; Liu, SW; Yen, MH; Chien, SL; Rong, JK Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8.1, 2 synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential alpha1-adrenoceptor antagonists. J Med Chem41:3128-41 (1998) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Histamine H1 receptor |
---|
Name: | Histamine H1 receptor |
Synonyms: | HISTAMINE H1 | HRH1 | HRH1_CAVPO |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 55641.53 |
Organism: | Cavia porcellus (domestic guinea pig) |
Description: | Guinea pig cerebellum was used in binding assay. |
Residue: | 488 |
Sequence: | MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYA
VRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVAS
TASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAP
TSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSL
PSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSE
DEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFP
ITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGC
IMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTF
KRILRIPP
|
|
|
BDBM50040253 |
---|
n/a |
---|
Name | BDBM50040253 |
Synonyms: | 3-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-1H-quinazoline-2,4-dione | CHEMBL51433 |
Type | Small organic molecule |
Emp. Form. | C21H24N4O3 |
Mol. Mass. | 380.4403 |
SMILES | COc1ccccc1N1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1 |
Structure |
|