Reaction Details |
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Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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Ligand | BDBM50066594 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_52887 (CHEMBL665411) |
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IC50 | 6200±n/a nM |
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Citation | Papageorgiou, C; Albert, R; Floersheim, P; Lemaire, M; Bitch, F; Weber, HP; Andersen, E; Hungerford, V; Schreier, MH Pyrazole bioisosteres of leflunomide as B-cell immunosuppressants for xenotransplantation and chronic rejection: scope and limitations. J Med Chem41:3530-8 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydroorotate dehydrogenase (quinone), mitochondrial |
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Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 42881.33 |
Organism: | Homo sapiens (Human) |
Description: | Q02127 |
Residue: | 395 |
Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
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BDBM50066594 |
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n/a |
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Name | BDBM50066594 |
Synonyms: | (4,5,6,7-Tetrahydro-1H-indazol-3-yl)-(4-trifluoromethyl-phenyl)-amine | CHEMBL118168 |
Type | Small organic molecule |
Emp. Form. | C14H14F3N3 |
Mol. Mass. | 281.2763 |
SMILES | FC(F)(F)c1ccc(Nc2[nH]nc3CCCCc23)cc1 |
Structure |
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