| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cathepsin B |
|---|
| Ligand | BDBM50067606 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_47416 (CHEMBL657293) |
|---|
| IC50 | 100±n/a nM |
|---|
| Citation |  Yasuma, T; Oi, S; Choh, N; Nomura, T; Furuyama, N; Nishimura, A; Fujisawa, Y; Sohda, T Synthesis of peptide aldehyde derivatives as selective inhibitors of human cathepsin L and their inhibitory effect on bone resorption. J Med Chem41:4301-8 (1998) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cathepsin B |
|---|
| Name: | Cathepsin B |
|---|
| Synonyms: | APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 37819.69 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_63102437 |
|---|
| Residue: | 339 |
|---|
| Sequence: | MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
|
|
|
|---|
| BDBM50067606 |
|---|
| n/a |
|---|
| Name | BDBM50067606 |
|---|
| Synonyms: | (S)-3-Methyl-2-(naphthalene-1-sulfonylamino)-pentanoic acid ((S)-1-formyl-3-methyl-butyl)-amide | CHEMBL134494 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H30N2O4S |
|---|
| Mol. Mass. | 418.55 |
|---|
| SMILES | CCC(C)[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@@H](CC(C)C)C=O |
|---|
| Structure | 
|
|---|
Search and Browse
