Reaction Details |
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Target | Phenylethanolamine N-methyltransferase |
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Ligand | BDBM50072979 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_152398 (CHEMBL764114) |
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Ki | 180±n/a nM |
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Citation | Grunewald, GL; Dahanukar, VH; Jalluri, RK; Criscione, KR Synthesis, biochemical evaluation, and classical and three-dimensional quantitative structure-activity relationship studies of 7-substituted-1,2,3,4-tetrahydroisoquinolines and their relative affinities toward phenylethanolamine N-methyltransferase and the alpha2-adrenoceptor. J Med Chem42:118-34 (1999) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Phenylethanolamine N-methyltransferase |
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Name: | Phenylethanolamine N-methyltransferase |
Synonyms: | Noradrenaline N-methyltransferase | PNMT | PNMT_BOVIN | PNMTase |
Type: | Enzyme |
Mol. Mass.: | 30916.97 |
Organism: | Bos taurus (bovine) |
Description: | n/a |
Residue: | 283 |
Sequence: | MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGA
FDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVS
AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVR
EALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
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BDBM50072979 |
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n/a |
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Name | BDBM50072979 |
Synonyms: | 7-Trifluoromethyl-1,2,3,4-tetrahydro-isoquinoline | CHEMBL27499 |
Type | Small organic molecule |
Emp. Form. | C10H10F3N |
Mol. Mass. | 201.1883 |
SMILES | FC(F)(F)c1ccc2CCNCc2c1 |
Structure |
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