Reaction Details |
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Target | Nitric oxide synthase, inducible |
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Ligand | BDBM22030 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_89369 (CHEMBL699602) |
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Ki | 25000±n/a nM |
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Citation | Huang, H; Martasek, P; Roman, LJ; Masters, BS; Silverman, RB N(omega)-Nitroarginine-containing dipeptide amides. Potent and highly selective inhibitors of neuronal nitric oxide synthase. J Med Chem42:3147-53 (1999) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Nitric oxide synthase, inducible |
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Name: | Nitric oxide synthase, inducible |
Synonyms: | Inducible NO synthase | Inducible NOS | Inducible nitric oxide synthase (iNOS) | Inosl | MAC-NOS | Macrophage NOS | NOS type II | NOS2_MOUSE | Nitric Oxide Synthase, inducible | Nitric oxide synthase, inducible (iNOS) | Nos2 |
Type: | Enzyme |
Mol. Mass.: | 130595.79 |
Organism: | Mus musculus (mouse) |
Description: | Recombinant enzyme overexpressed in E. coli. |
Residue: | 1144 |
Sequence: | MACPWKFLFKVKSYQSDLKEEKDINNNVKKTPCAVLSPTIQDDPKSHQNGSPQLLTGTAQ
NVPESLDKLHVTSTRPQYVRIKNWGSGEILHDTLHHKATSDFTCKSKSCLGSIMNPKSLT
RGPRDKPTPLEELLPHAIEFINQYYGSFKEAKIEEHLARLEAVTKEIETTGTYQLTLDEL
IFATKMAWRNAPRCIGRIQWSNLQVFDARNCSTAQEMFQHICRHILYATNNGNIRSAITV
FPQRSDGKHDFRLWNSQLIRYAGYQMPDGTIRGDAATLEFTQLCIDLGWKPRYGRFDVLP
LVLQADGQDPEVFEIPPDLVLEVTMEHPKYEWFQELGLKWYALPAVANMLLEVGGLEFPA
CPFNGWYMGTEIGVRDFCDTQRYNILEEVGRRMGLETHTLASLWKDRAVTEINVAVLHSF
QKQNVTIMDHHTASESFMKHMQNEYRARGGCPADWIWLVPPVSGSITPVFHQEMLNYVLS
PFYYYQIEPWKTHIWQNEKLRPRRREIRFRVLVKVVFFASMLMRKVMASRVRATVLFATE
TGKSEALARDLATLFSYAFNTKVVCMDQYKASTLEEEQLLLVVTSTFGNGDCPSNGQTLK
KSLFMLRELNHTFRYAVFGLGSSMYPQFCAFAHDIDQKLSHLGASQLAPTGEGDELSGQE
DAFRSWAVQTFRAACETFDVRSKHHIQIPKRFTSNATWEPQQYRLIQSPEPLDLNRALSS
IHAKNVFTMRLKSQQNLQSEKSSRTTLLVQLTFEGSRGPSYLPGEHLGIFPGNQTALVQG
ILERVVDCPTPHQTVCLEVLDESGSYWVKDKRLPPCSLSQALTYFLDITTPPTQLQLHKL
ARFATDETDRQRLEALCQPSEYNDWKFSNNPTFLEVLEEFPSLHVPAAFLLSQLPILKPR
YYSISSSQDHTPSEVHLTVAVVTYRTRDGQGPLHHGVCSTWIRNLKPQDPVPCFVRSVSG
FQLPEDPSQPCILIGPGTGIAPFRSFWQQRLHDSQHKGLKGGRMSLVFGCRHPEEDHLYQ
EEMQEMVRKRVLFQVHTGYSRLPGKPKVYVQDILQKQLANEVLSVLHGEQGHLYICGDVR
MARDVATTLKKLVATKLNLSEEQVEDYFFQLKSQKRYHEDIFGAVFSYGAKKGSALEEPK
ATRL
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BDBM22030 |
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n/a |
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Name | BDBM22030 |
Synonyms: | (2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)propyl]-5-{[(E)-imino(nitroamino)methyl]amino}pentanamide | (2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)propyl]-5-{[(Z)-imino(nitroamino)methyl]amino}pentanamide | (2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)propyl]-5-{[imino(nitroamino)methyl]amino}pentanamide | (2S)-2-amino-N-[(1S)-3-amino-1-carbamoylpropyl]-5-(1-nitrocarbamimidamido)pentanamide | CHEMBL1204421 | CHEMBL44833 | CHEMBL481413 | JMC522060 Compound 1 | L-Arg NO2-L-Dbu-NH2 | L-N(OMEGA)-NITROARGININE-2,4-L-DIAMINOBUTYRIC AMIDE | L-Nomega-nitroarginine-2,4-L-diaminobutyramide | dipeptide amide inhibitor I |
Type | Small organic molecule |
Emp. Form. | C10H22N8O4 |
Mol. Mass. | 318.3329 |
SMILES | NCC[C@H](NC(=O)[C@@H](N)CCCN=C(N)N[N+]([O-])=O)C(N)=O |r,w:12.11| |
Structure |
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