| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histamine H1 receptor |
|---|
| Ligand | BDBM112777 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_84698 (CHEMBL692702) |
|---|
| IC50 | 0.05±n/a nM |
|---|
| Citation |  Quiñones-Torrelo, C; Sagrado, S; Villanueva-Camañas, RM; Medina-Hernández, MJ Development of predictive retention-activity relationship models of tricyclic antidepressants by micellar liquid chromatography. J Med Chem42:3154-62 (1999) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histamine H1 receptor |
|---|
| Name: | Histamine H1 receptor |
|---|
| Synonyms: | HISTAMINE H1 | HRH1_RAT | Hrh1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 55716.35 |
|---|
| Organism: | RAT |
|---|
| Description: | HISTAMINE H1 HRH1 RAT::P31390 |
|---|
| Residue: | 486 |
|---|
| Sequence: | MSFANTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVHSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLRYRTKTRASATILGAWFFSFLWVIPILGWHHFMPPAPELREDKC
ETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPSFSELKLR
SDDTKEGAKKPGRESPWGVLKRPSRDPSVGLDQKSTSEDPKMTSPTVFSQEGERETRPCF
RLDIMQKQSVAEGDVRGSKANDQALSQPKMDEQSLNTCRRISETSEDQTLVDQQSFSRTT
DSDTSIEPGPGRVKSRSGSNSGLDYIKITWKRLRSHSRQYVSGLHLNRERKAAKQLGFIM
AAFILCWIPYFIFFMVIAFCKSCCSEPMHMFTIWLGYINSTLNPLIYPLCNENFKKTFKK
ILHIRS
|
|
|
|---|
| BDBM112777 |
|---|
| n/a |
|---|
| Name | BDBM112777 |
|---|
| Synonyms: | NORTRIPTYLINE | US8629135, SW-02 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H21N |
|---|
| Mol. Mass. | 263.3767 |
|---|
| SMILES | [#6]-[#7]-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12 |
|---|
| Structure | 
|
|---|
Search and Browse
