| Reaction Details |
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 | Report a problem with these data |
| Target | Tumor necrosis factor |
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| Ligand | BDBM50081332 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_212403 (CHEMBL816155) |
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| IC50 | >25000±n/a nM |
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| Citation |  Chao, Q; Deng, L; Shih, H; Leoni, LM; Genini, D; Carson, DA; Cottam, HB Substituted isoquinolines and quinazolines as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha. J Med Chem42:3860-73 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Tumor necrosis factor |
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| Name: | Tumor necrosis factor |
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| Synonyms: | Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha |
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| Type: | Enzyme |
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| Mol. Mass.: | 25645.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P01375 |
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| Residue: | 233 |
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| Sequence: | MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
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| BDBM50081332 |
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| n/a |
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| Name | BDBM50081332 |
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| Synonyms: | 4-(5-Azido-6,7-dimethoxy-4-oxo-4H-quinazolin-3-yl)-butyric acid ethyl ester | CHEMBL338340 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H19N5O5 |
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| Mol. Mass. | 361.3526 |
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| SMILES | CCOC(=O)CCCn1cnc2cc(OC)c(OC)c(N=[N+]=[N-])c2c1=O |
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| Structure | 
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