Reaction Details |
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Target | Alpha-1A adrenergic receptor |
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Ligand | BDBM50033111 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_33739 (CHEMBL873186) |
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Ki | 6.9±n/a nM |
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Citation | Nagarathnam, D; Miao, SW; Lagu, B; Chiu, G; Fang, J; Murali Dhar, TG; Zhang, J; Tyagarajan, S; Marzabadi, MR; Zhang, F; Wong, WC; Sun, W; Tian, D; Wetzel, JM; Forray, C; Chang, RS; Broten, TP; Ransom, RW; Schorn, TW; Chen, TB; O'Malley, S; Kling, P; Schneck, K; Bendesky, R; Harrell, CM Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 1. Structure-activity relationship in dihydropyrimidinones. J Med Chem42:4764-77 (1999) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Alpha-1A adrenergic receptor |
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Name: | Alpha-1A adrenergic receptor |
Synonyms: | ADA1A_HUMAN | ADRA1A | ADRA1C | Adrenergic alpha1A | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha adrenergic receptor 1a | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 | adrenergic Alpha1C |
Type: | Cell-surface receptors |
Mol. Mass.: | 51511.67 |
Organism: | Homo sapiens (Human) |
Description: | P35348 |
Residue: | 466 |
Sequence: | MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
TARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
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BDBM50033111 |
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n/a |
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Name | BDBM50033111 |
Synonyms: | 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine | 6,7-dimethoxy-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine | CHEMBL611 | TERAZOSIN | Terazosine |
Type | Small organic molecule |
Emp. Form. | C19H25N5O4 |
Mol. Mass. | 387.4329 |
SMILES | COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 |
Structure |
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