| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 3A/3B |
|---|
| Ligand | BDBM50083190 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2986 (CHEMBL621503) |
|---|
| Ki | 0.13±n/a nM |
|---|
| Citation |  López-Rodríguez, ML; Benhamú, B; Morcillo, MJ; Tejada, ID; Orensanz, L; Alfaro, MJ; Martín, MI Benzimidazole derivatives. 2. Synthesis and structure-activity relationships of new azabicyclic benzimidazole-4-carboxylic acid derivatives with affinity for serotoninergic 5-HT(3) receptors. J Med Chem42:5020-8 (2000) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 5-hydroxytryptamine receptor 3A/3B |
|---|
| Name: | 5-hydroxytryptamine receptor 3A/3B |
|---|
| Synonyms: | Serotonin 3 (5-HT3) receptor | Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of EBI is 2974 |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | 5-hydroxytryptamine receptor 3B |
|---|
| Synonyms: | 5HT3B_RAT | Htr3b | Serotonin (5-HT) receptor |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 50328.78 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | EBI_11885 |
|---|
| Residue: | 437 |
|---|
| Sequence: | MILLWSCLLVAVVGILGTATPQPGNSSLHRLTRQLLQQYHKEVRPVYNWAEATTVYLDLC
VHAVLDVDVQNQKLKTSMWYREVWNDEFLSWNSSLFDDIQEISLPLSAIWAPDIIINEFV
DVERSPDLPYVYVNSSGTIRNHKPIQVVSACSLQTYAFPFDIQNCSLTFNSILHTVEDID
LGFLRNQEDIENDKRSFLNDSEWQLLSVTSTYHIRQSSAGDFAQIRFNVVIRRCPLAYVV
SLLIPSIFLMLVDLGSFYLPPNCRARIVFKTNVLVGYTVFRVNMSDEVPRSAGCTSLIGV
FFTVCMALLVLSLSKSILLIKFLYEERHSEQERPLMCLRGDSDANESRLYLRAPCAEDTE
SPVRQEHQVPSDTLKDFWFQLQSINNSLRTRDQVYQKEVEWLAILCHFDQLLFRIYLAVL
GLYTVTLCSLWALWSRM
|
|
|
|---|
| Component 2 |
| Name: | 5-hydroxytryptamine receptor 3A |
|---|
| Synonyms: | 5-HT3 | 5-hydroxytryptamine receptor 3A | 5HT3A_RAT | 5ht3 | Htr3 | Htr3a | Serotonin (5-HT) receptor | Zacopride site-R |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 55428.70 |
|---|
| Organism: | RAT |
|---|
| Description: | 5-HT3 HTR3A RAT::P35563 |
|---|
| Residue: | 483 |
|---|
| Sequence: | MPLCIPQVLLALFLSVLIAQGEGSRRRATQAHSTTQPALLRLSDHLLANYKKGVRPVRDW
RKPTLVSIDVIMYAILNVDEKNQVLTTYIWYRQFWTDEFLQWTPEDFDNVTKLSIPTDSI
WVPDILINEFVDVGKSPSIPYVYVHHQGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTF
TSWLHTIQDINISLWRTPEEVRSDKSIFINQGEWELLGVFTKFQEFSIETSNSYAEMKFY
VVIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTL
PATAIGTPLIGVYFVVCMALLVISLAETIFIVQLVHKQDLQRPVPDWLRHLVLDRIAWLL
CLGEQPMAHRPPATFQANKTDDCSAMGNHCSHVGSPQDLEKTSRSRDSPLPPPREASLAV
RGLLQELSSIRHSLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIW
HYS
|
|
|
|---|
| BDBM50083190 |
|---|
| n/a |
|---|
| Name | BDBM50083190 |
|---|
| Synonyms: | 6-Chloro-1H-benzoimidazole-4-carboxylic acid (1-aza-bicyclo[2.2.2]oct-3-yl)-amide | CHEMBL149558 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H17ClN4O |
|---|
| Mol. Mass. | 304.775 |
|---|
| SMILES | Clc1cc(C(=O)N[C@@H]2CN3CCC2CC3)c2[nH]cnc2c1 |wU:7.6,(6.26,-6.07,;7.6,-6.85,;8.93,-6.07,;10.26,-6.82,;11.6,-6.07,;11.57,-4.52,;12.93,-6.82,;14.25,-6.05,;14.25,-7.6,;15.57,-6.8,;14.39,-5.37,;14.46,-4.26,;15.75,-5.65,;17.23,-6.03,;17.07,-7.2,;10.26,-8.38,;11.41,-9.43,;10.8,-10.84,;9.27,-10.68,;8.94,-9.18,;7.6,-8.38,)| |
|---|
| Structure | 
|
|---|
Search and Browse
