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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 5-hydroxytryptamine receptor 3A/3B | ||
| Ligand | BDBM50083194 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2986 (CHEMBL621503) | ||
| Ki | 5.2±n/a nM | ||
| Citation |  López-Rodríguez, ML; Benhamú, B; Morcillo, MJ; Tejada, ID; Orensanz, L; Alfaro, MJ; Martín, MI Benzimidazole derivatives. 2. Synthesis and structure-activity relationships of new azabicyclic benzimidazole-4-carboxylic acid derivatives with affinity for serotoninergic 5-HT(3) receptors. J Med Chem42:5020-8 (2000) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 5-hydroxytryptamine receptor 3A/3B | |||
| Name: | 5-hydroxytryptamine receptor 3A/3B | ||
| Synonyms: | Serotonin 3 (5-HT3) receptor | Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor | ||
| Type: | n/a | ||
| Mol. Mass.: | n/a | ||
| Description: | ASSAY_ID of EBI is 2974 | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | 5-hydroxytryptamine receptor 3B | ||
| Synonyms: | 5HT3B_RAT | Htr3b | Serotonin (5-HT) receptor | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 50328.78 | ||
| Organism: | Rattus norvegicus | ||
| Description: | EBI_11885 | ||
| Residue: | 437 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | 5-hydroxytryptamine receptor 3A | ||
| Synonyms: | 5-HT3 | 5-hydroxytryptamine receptor 3A | 5HT3A_RAT | 5ht3 | Htr3 | Htr3a | Serotonin (5-HT) receptor | Zacopride site-R | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 55428.70 | ||
| Organism: | RAT | ||
| Description: | 5-HT3 HTR3A RAT::P35563 | ||
| Residue: | 483 | ||
| Sequence: |
| ||
| BDBM50083194 | |||
| n/a | |||
| Name | BDBM50083194 | ||
| Synonyms: | 6-Chloro-7-nitro-1H-benzoimidazole-4-carboxylic acid (1-aza-bicyclo[2.2.2]oct-3-yl)-amide | CHEMBL148072 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C15H16ClN5O3 | ||
| Mol. Mass. | 349.772 | ||
| SMILES | [O-][N+](=O)c1c(Cl)cc(C(=O)NC2CN3CCC2CC3)c2[nH]cnc12 |(5.24,-8.26,;6.4,-9.09,;6.56,-10.59,;7.9,-8.3,;7.9,-6.75,;6.57,-5.96,;9.23,-5.98,;10.57,-6.75,;11.9,-5.96,;11.88,-4.43,;13.24,-6.72,;14.56,-5.94,;14.54,-7.49,;15.89,-6.71,;14.7,-5.26,;14.77,-4.17,;16.05,-5.55,;17.53,-5.93,;17.36,-7.1,;10.57,-8.3,;11.71,-9.32,;11.11,-10.73,;9.57,-10.59,;9.26,-9.09,)| | ||
| Structure | 
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