| Reaction Details |
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 | Report a problem with these data |
| Target | Corticotropin-releasing factor receptor 1 |
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| Ligand | BDBM50074429 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_51131 (CHEMBL664192) |
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| Ki | 36±n/a nM |
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| Citation |  Hodge, CN; Aldrich, PE; Wasserman, ZR; Fernandez, CH; Nemeth, GA; Arvanitis, A; Cheeseman, RS; Chorvat, RJ; Ciganek, E; Christos, TE; Gilligan, PJ; Krenitsky, P; Scholfield, E; Strucely, P Corticotropin-releasing hormone receptor antagonists: framework design and synthesis guided by ligand conformational studies. J Med Chem42:819-32 (1999) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Corticotropin-releasing factor receptor 1 |
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| Name: | Corticotropin-releasing factor receptor 1 |
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| Synonyms: | CRF-R | CRF1 | CRFR1_RAT | CRH-R 1 | Corticotropin releasing factor receptor | Corticotropin releasing factor receptor 1 | Corticotropin-releasing Factor Receptor 1 | Corticotropin-releasing hormone receptor 1 | Crhr | Crhr1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 47870.75 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Receptor binding assays were performed using rat cortex homogenate. |
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| Residue: | 415 |
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| Sequence: | MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEV
HQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPF
PIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA
STTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVS
VFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
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| BDBM50074429 |
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| n/a |
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| Name | BDBM50074429 |
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| Synonyms: | 1-(2-Bromo-4-isopropyl-phenyl)-6-methyl-4-phenyl-1H-pyrrolo[2,3-b]pyridine | CHEMBL169359 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H21BrN2 |
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| Mol. Mass. | 405.33 |
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| SMILES | CC(C)c1ccc(c(Br)c1)-n1ccc2c(cc(C)nc12)-c1ccccc1 |
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| Structure | 
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