| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50088243 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_65648 (CHEMBL678560) |
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| Ki | 400±n/a nM |
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| Citation |  Wintner, EA; Moallemi, CC Quantized surface complementarity diversity (QSCD): a model based on small molecule-target complementarity. J Med Chem43:1993-2006 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48736.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25101 |
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| Residue: | 427 |
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| Sequence: | METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
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| BDBM50088243 |
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| n/a |
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| Name | BDBM50088243 |
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| Synonyms: | 3-Benzo[1,3]dioxol-5-yl-4-benzyl-5-(3,4-dichloro-phenyl)-5-hydroxy-dihydro-furan-2-one | CHEMBL64200 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H18Cl2O5 |
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| Mol. Mass. | 457.303 |
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| SMILES | O[C@]1(OC(=O)C(C1Cc1ccccc1)c1ccc2OCOc2c1)c1ccc(Cl)c(Cl)c1 |
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| Structure | 
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