Reaction Details |
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Target | Sodium-dependent noradrenaline transporter |
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Ligand | BDBM50088327 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_142794 (CHEMBL752762) |
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Ki | 68±n/a nM |
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Citation | Hoepping, A; Johnson, KM; George, C; Flippen-Anderson, J; Kozikowski, AP Novel conformationally constrained tropane analogues by 6-endo-trig radical cyclization and stille coupling - switch of activity toward the serotonin and/or norepinephrine transporter. J Med Chem43:2064-71 (2000) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent noradrenaline transporter |
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Name: | Sodium-dependent noradrenaline transporter |
Synonyms: | Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2 |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 69337.72 |
Organism: | Homo sapiens (Human) |
Description: | P23975 |
Residue: | 617 |
Sequence: | MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
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BDBM50088327 |
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n/a |
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Name | BDBM50088327 |
Synonyms: | 9-Benzylidene-7-aza-tricyclo[4.3.1.0*3,7*]decane-2-carboxylic acid methyl ester | CHEMBL294105 |
Type | Small organic molecule |
Emp. Form. | C18H21NO2 |
Mol. Mass. | 283.3648 |
SMILES | COC(=O)[C@H]1C2CC[C@@H]3C[C@@H]1\C(CN23)=C\c1ccccc1 |TLB:7:8:4.5:11.12,THB:11:10:13:6.7,12:13:4.10.9:6.7,2:4:13:6.7| |
Structure |
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