| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A1 |
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| Ligand | BDBM50090683 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_29105 (CHEMBL638717) |
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| Ki | 5.3±n/a nM |
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| Citation |  Ferrarini, PL; Mori, C; Manera, C; Martinelli, A; Mori, F; Saccomanni, G; Barili, PL; Betti, L; Giannaccini, G; Trincavelli, L; Lucacchini, A A novel class of highly potent and selective A1 adenosine antagonists: structure-affinity profile of a series of 1,8-naphthyridine derivatives. J Med Chem43:2814-23 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A1 |
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| Name: | Adenosine receptor A1 |
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| Synonyms: | AA1R_BOVIN | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | ADORA1 | Adenosine A1 receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 36602.99 |
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| Organism: | BOVINE |
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| Description: | ADENOSINE 0 BOVINE::P28190 |
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| Residue: | 326 |
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| Sequence: | MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPRTYFHTCLKVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVT
PRRAVVAITGCWILSFVVGLTPMFGWNNLSAVERDWLANGSVGEPVIECQFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYMEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPSCHMPRILIYIAIFLSHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPAPPVDEDAPAERPDD
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| BDBM50090683 |
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| n/a |
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| Name | BDBM50090683 |
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| Synonyms: | 7-Amino-2-phenyl-1H-[1,8]naphthyridin-4-one | 7-Amino-2-phenyl-[1,8]naphthyridin-4-ol | CHEMBL102430 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H11N3O |
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| Mol. Mass. | 237.2566 |
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| SMILES | Nc1ccc2c(O)cc(nc2n1)-c1ccccc1 |
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| Structure | 
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