Ki Summary

Reaction Details

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Target

Adenosine receptor A3

Ligand

BDBM50207816

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_31246 (CHEMBL642211)

418±n/a nM

Citation

Ferrarini, PL; Mori, C; Manera, C; Martinelli, A; Mori, F; Saccomanni, G; Barili, PL; Betti, L; Giannaccini, G; Trincavelli, L; Lucacchini, A A novel class of highly potent and selective A1 adenosine antagonists: structure-affinity profile of a series of 1,8-naphthyridine derivatives. J Med Chem43:2814-23 (2000) [PubMed]

More Info.:

Get all data from this article, Assay Method

Adenosine receptor A3

Name:

Adenosine receptor A3

Synonyms:

AA3R_RAT | Adenosine A3 receptor | Adenosine receptor A2a and A3 | Adora3

Type:

PROTEIN

Mol. Mass.:

36643.73

Organism:

Rattus norvegicus

Description:

ChEMBL_479910

Residue:

320

Sequence:

MKANNTTTSALWLQITYITMEAAIGLCAVVGNMLVIWVVKLNRTLRTTTFYFIVSLALAD
IAVGVLVIPLAIAVSLEVQMHFYACLFMSCVLLVFTHASIMSLLAIAVDRYLRVKLTVRY
RTVTTQRRIWLFLGLCWLVSFLVGLTPMFGWNRKVTLELSQNSSTLSCHFRSVVGLDYMV
FFSFITWILIPLVVMCIIYLDIFYIIRNKLSQNLTGFRETRAFYGREFKTAKSLFLVLFL
FALCWLPLSIINFVSYFNVKIPEIAMCLGILLSHANSMMNPIVYACKIKKFKETYFVILR
ACRLCQTSDSLDSNLEQTTE

BDBM50207816

n/a

Name

BDBM50207816

Synonyms:

CHEMBL273094 | N-(2-Amino-ethyl)-2-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetamide | N-(2-Amino-ethyl)-2-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetamide (xanthine amine congenere, XAC) | N-(2-Amino-ethyl)-2-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetamide(XAC) | N-(2-Amino-ethyl)-2-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,9-tetrahydro-1H-purin-8-yl)-phenoxy]-acetamide | N-(2-aminoethyl)-2-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)phenoxy)acetamide | XAC

Type

Small organic molecule

Emp. Form.

C21H28N6O4

Mol. Mass.

428.4848

SMILES

CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1ccc(OCC(=O)NCCN)cc1

Structure