| Reaction Details |
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 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
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| Ligand | BDBM50091009 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_145508 (CHEMBL752150) |
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| Ki | 78±n/a nM |
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| Citation |  Ronsisvalle, G; Pasquinucci, L; Pittalà, V; Marrazzo, A; Prezzavento, O; Di Toro, R; Falcucci, B; Spampinato, S Nonpeptide analogues of dynorphin A(1-8): design, synthesis, and pharmacological evaluation of kappa-selective agonists. J Med Chem43:2992-3004 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Kappa-type opioid receptor |
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| Name: | Kappa-type opioid receptor |
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| Synonyms: | Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42744.99 |
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| Organism: | Cavia porcellus (domestic guinea pig) |
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| Description: | P41144 |
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| Residue: | 380 |
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| Sequence: | MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRV
RNTVQDPAYMRNVDGVNKPV
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| BDBM50091009 |
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| n/a |
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| Name | BDBM50091009 |
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| Synonyms: | 2-[5-Guanidino-2-(5-guanidino-2-{[2-(8-hydroxy-6,11-dimethyl-1,2,5,6-tetrahydro-4H-2,6-methano-benzo[d]azocin-3-ylmethyl)-1-phenyl-cyclopropanecarbonyl]-amino}-pentanoylamino)-pentanoylamino]-3-methyl-pentanoic acid methyl ester(MPCB-RRI) | CHEMBL408096 |
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| Type | Small organic molecule |
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| Emp. Form. | C44H66N10O6 |
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| Mol. Mass. | 831.0582 |
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| SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@]1(C[C@@H]1CN1CC[C@]2(C)C(C)C1Cc1ccc(O)cc21)c1ccccc1)C(=O)OC |TLB:33:34:39:49.43.42,THB:48:49:39:34.36.35| |
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| Structure | 
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