Reaction Details |
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Target | Collagenase 3 |
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Ligand | BDBM12075 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_106476 (CHEMBL719145) |
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IC50 | 8±n/a nM |
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Citation | O'Brien, PM; Ortwine, DF; Pavlovsky, AG; Picard, JA; Sliskovic, DR; Roth, BD; Dyer, RD; Johnson, LL; Man, CF; Hallak, H Structure-activity relationships and pharmacokinetic analysis for a series of potent, systemically available biphenylsulfonamide matrix metalloproteinase inhibitors. J Med Chem43:156-66 (2000) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Collagenase 3 |
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Name: | Collagenase 3 |
Synonyms: | MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13) |
Type: | Enzyme |
Mol. Mass.: | 53808.06 |
Organism: | Homo sapiens (Human) |
Description: | P45452 |
Residue: | 471 |
Sequence: | MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENA
ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY
RIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDG
PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM
FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGET
MIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGY
DILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI
EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
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BDBM12075 |
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n/a |
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Name | BDBM12075 |
Synonyms: | (2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-methylbutanoic acid | CHEMBL43152 | alpha-arylsulfonylamino carboxylate 2S |
Type | Small organic molecule |
Emp. Form. | C17H18BrNO4S |
Mol. Mass. | 412.298 |
SMILES | CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1)C(O)=O |r| |
Structure |
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