Reaction Details |
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Target | Interstitial collagenase |
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Ligand | BDBM50084289 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_105961 (CHEMBL715374) |
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IC50 | 1500±n/a nM |
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Citation | O'Brien, PM; Ortwine, DF; Pavlovsky, AG; Picard, JA; Sliskovic, DR; Roth, BD; Dyer, RD; Johnson, LL; Man, CF; Hallak, H Structure-activity relationships and pharmacokinetic analysis for a series of potent, systemically available biphenylsulfonamide matrix metalloproteinase inhibitors. J Med Chem43:156-66 (2000) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Interstitial collagenase |
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Name: | Interstitial collagenase |
Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
Type: | Enzyme |
Mol. Mass.: | 54010.26 |
Organism: | Homo sapiens (Human) |
Description: | P03956 |
Residue: | 469 |
Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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BDBM50084289 |
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n/a |
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Name | BDBM50084289 |
Synonyms: | (S)-2-(4'-methoxy-biphenyl-4-sulfonylamino)-3-methyl-butyric acid | 2-(4'-Methoxy-biphenyl-4-sulfonylamino)-3-methyl-butyric acid | CHEMBL44383 |
Type | Small organic molecule |
Emp. Form. | C18H21NO5S |
Mol. Mass. | 363.428 |
SMILES | COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)C(O)=O |
Structure |
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