| Reaction Details |
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 | Report a problem with these data |
| Target | Tripeptidyl-peptidase 2 |
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| Ligand | BDBM50085078 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_211948 (CHEMBL816538) |
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| Ki | 29000±n/a nM |
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| Citation |  Ganellin, CR; Bishop, PB; Bambal, RB; Chan, SM; Law, JK; Marabout, B; Luthra, PM; Moore, AN; Peschard, O; Bourgeat, P; Rose, C; Vargas, F; Schwartz, JC Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J Med Chem43:664-74 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Tripeptidyl-peptidase 2 |
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| Name: | Tripeptidyl-peptidase 2 |
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| Synonyms: | TPP2_RAT | Tpp2 | Tripeptidyl aminopeptidase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 138287.08 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_211948 |
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| Residue: | 1249 |
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| Sequence: | MATAATEEPFPFHGLLPKKETGASSFLCRYPEYDGRGVLIAVLDTGVDPGAPGMQVTTDG
KPKIIDIIDTTGSGDVNTATEVEPKDGEITGLSGRVLKIPANWTNPSGKYHIGIKNGYDF
YPKALKERIQKERKEKIWDPIHRVALAEACRKQEEFDIANNGSSQANKLIKEELQSQVEL
LNSFEKKYSDPGPVYDCLVWHDGETWRACVDSNENGDLGKSTVLRNYKEAQEYGSFGTAE
MLNYSVNIYDDGNLLSIVTSGGAHGTHVASIAAGHFPEEPERNGVAPGAQILSIKIGDTR
LSTMETGTGLIRAMIEVINHKCDLVNYSYGEATHWPNSGRICEVINEAVWKHNTIYVSSA
GNNGPCLSTVGCPGGTTSSVIGVGAYVSPDMMVAEYSLREKLPANQYTWSSRGPSADGAL
GVSISAPGGAIASVPNWTLRGTQLMNGTSMSSPNACGGIALVLSGLKANNVDYTVHSVRR
ALENTAIKADNIEVFAQGHGIIQVDKAYDYLIQNTSFANRLGFTVTVGNNRGIYLRDPVQ
VAAPSDHGVGIEPVFPENTENSEKISFQLHLALTSNSSWVQCPSHLELMNQCRHINIRVD
PRGLREGLHYTEVCGYDIASPNAGPLFRVPITAVIAAKVNESSHYDLAFTDVHFKPGQIR
RHFVEVPEGATWAEVTVCSCSSEVSAKFVLHAVQLVKQRAYRSHEFYKFCSLPEKGTLIE
AFPVLGGKAIEFCIARWWASLSDVNIDYTISFHGIVCTAPQLNIHASEGINRFDVQSSLK
YEDLAPCITLKSWVQTLRPVNAKTRPLGSRDVLPNNRQLYEMVLTYSFHQPKSGEVTPSC
PLLCELLYESEFDSQLWIIFDQNKRQMGSGDAYPHQYSLKLEKGDYTIRLQIRHEQISDL
DRLKDLPFIVSHRLSNTLSLDIHENHSLALLGKKKSSSLTLPPKYNQPFFVTSLPDDKIP
KGAGPGCYLAGSLTLSKTELGKKADVIPVHYYLIPPPTKTKNGSKDKEKDSEKEKDLKEE
FTEALRDLKIQWMTKLDSTDIYNELKETYPAYLPLYVARLHQLDAEKERMKRLNEIVDAA
NAVISHIDQTALAVYIAMKTDPRPDAATIKNDMDKQKSTLVDALCRKGCALADHLLHAQP
HDGAAAGDAEAKEEEGESTLESLSETYWETTKWTDLFDTKVLTFAYKHALVNKMYGRGLK
FATKLVEEKPTKENWKNCIQLMKLLGWTHCASFTENWLPIMYPPDYCVF
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| BDBM50085078 |
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| n/a |
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| Name | BDBM50085078 |
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| Synonyms: | 2-(2-Amino-3-methyl-butyrylamino)-hexanoic acid (3-phenyl-propyl)-amide (0.25H2O) | CHEMBL161497 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H33N3O2 |
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| Mol. Mass. | 347.4949 |
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| SMILES | CCCCC(NC(=O)C(N)C(C)C)C(=O)NCCCc1ccccc1 |
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| Structure | 
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