Reaction Details |
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Target | ATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11 |
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Ligand | BDBM50099576 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_198601 (CHEMBL805674) |
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Kd | 5200±n/a nM |
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Citation | Coghlan, MJ; Carroll, WA; Gopalakrishnan, M Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress. J Med Chem44:1627-53 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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ATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11 |
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Name: | ATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11 |
Synonyms: | Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 | Sulfonylurea receptor 2, Kir6.2 |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of EBI is 46128 |
Components: | This complex has 2 components. |
Component 1 |
Name: | ATP-binding cassette sub-family C member 9 |
Synonyms: | ABCC9 | ABCC9_HUMAN | ATP-binding cassette transporter sub-family C member 9 | SUR2 | Sulfonylurea receptor 2 | Sulfonylurea receptor 2, Kir6.2 |
Type: | PROTEIN |
Mol. Mass.: | 174236.59 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_495672 |
Residue: | 1549 |
Sequence: | MSLSFCGNNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHH
NTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIV
YYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLL
MAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHK
KPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLS
STFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFL
ALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIE
TNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEA
QKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSI
FMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAII
SVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTR
RLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILG
EMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQR
YKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFS
ALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQ
TKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEE
EDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTS
EYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGP
IRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALL
PLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLE
LTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITN
YLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVR
YENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKL
PLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDA
VVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTV
VTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLVMTNK
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Component 2 |
Name: | ATP-sensitive inward rectifier potassium channel 11 |
Synonyms: | ATP-sensitive inward rectifier potassium channel 11 | IKATP | Inward rectifier K(+) channel Kir6.2 | KCJ11_HUMAN | KCNJ11 | Potassium channel, inwardly rectifying subfamily J member 11 | Potassium channel, inwardly rectifying, subfamily J, member 11 | Sulfonylurea receptor 1, Kir6.2 | Sulfonylurea receptor 2, Kir6.2 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 43549.41 |
Organism: | Homo sapiens (Human) |
Description: | Potassium channel (ATP modulatory) 0 0::Q14654 |
Residue: | 390 |
Sequence: | MLSRKGIIPEEYVLTRLAEDPAEPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDVF
TTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSA
FLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAET
LIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPM
ENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQA
RTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLDEDHSLLEALT
LASARGPLRKRSVPMAKAKPKFSISPDSLS
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BDBM50099576 |
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n/a |
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Name | BDBM50099576 |
Synonyms: | 1-(4-Imidazol-1-yl-benzoyl)-cyclobutanecarbothioic acid methylamide | CHEMBL47088 |
Type | Small organic molecule |
Emp. Form. | C16H17N3OS |
Mol. Mass. | 299.391 |
SMILES | CNC(=S)C1(CCC1)C(=O)c1ccc(cc1)-n1ccnc1 |
Structure |
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