Ki Summary

Reaction Details

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Target

Mu-type opioid receptor

Ligand

BDBM50100462

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_149630 (CHEMBL756698)

81.8±n/a nM

Citation

Sharma, SK; Jones, RM; Metzger, TG; Ferguson, DM; Portoghese, PS Transformation of a kappa-opioid receptor antagonist to a kappa-agonist by transfer of a guanidinium group from the 5'- to 6'-position of naltrindole. J Med Chem44:2073-9 (2001) [PubMed]

More Info.:

Get all data from this article, Assay Method

Mu-type opioid receptor

Name:

Mu-type opioid receptor

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

44503.11

Organism:

Rattus norvegicus (rat)

Description:

Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.

Residue:

398

Sequence:

MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP

BDBM50100462

n/a

Name

BDBM50100462

Synonyms:

6`-guanidino-17-(cyclopropylmethyl)-6,7-didehydro-4,5alpha-epoxy-3,14-hydroxyindolo-[2`,3`:6,7]morphinian

Type

Small organic molecule

Emp. Form.

C27H29N5O3

Mol. Mass.

471.5509

SMILES

NC(N)=Nc1ccc2c3C[C@@]4(O)C5Cc6ccc(O)c7O[C@@H](c3[nH]c2c1)[C@]4(CCN5CC1CC1)c67 |wU:10.10,wD:26.39,21.20,THB:19:34:10:29.27.28,15:14:10:29.27.28,(16.18,-14.68,;17.06,-15.94,;18.6,-15.8,;16.41,-17.34,;14.87,-17.48,;14,-16.22,;12.47,-16.36,;11.84,-17.76,;10.38,-18.21,;9.06,-17.41,;7.72,-18.16,;8.12,-16.67,;6.39,-17.38,;5.05,-18.14,;5.04,-19.68,;3.72,-20.45,;3.72,-21.99,;5.04,-22.76,;5.04,-24.3,;6.37,-21.99,;8.59,-21.98,;9.01,-20.49,;10.36,-19.75,;11.81,-20.24,;12.72,-19,;14.24,-18.86,;7.68,-19.7,;5.72,-18.42,;5.32,-16.92,;6.42,-15.84,;5.09,-15.06,;5.09,-13.52,;4.32,-12.18,;5.88,-12.19,;6.37,-20.45,)|

Structure