| Reaction Details |
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 | Report a problem with these data |
| Target | Gag-Pol polyprotein [489-587] |
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| Ligand | BDBM50101482 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_159290 (CHEMBL766055) |
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| IC50 | 0.28±n/a nM |
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| Citation |  Hagen, SE; Domagala, J; Gajda, C; Lovdahl, M; Tait, BD; Wise, E; Holler, T; Hupe, D; Nouhan, C; Urumov, A; Zeikus, G; Zeikus, E; Lunney, EA; Pavlovsky, A; Gracheck, SJ; Saunders, J; VanderRoest, S; Brodfuehrer, J 4-Hydroxy-5,6-dihydropyrones as inhibitors of HIV protease: the effect of heterocyclic substituents at C-6 on antiviral potency and pharmacokinetic parameters. J Med Chem44:2319-32 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Gag-Pol polyprotein [489-587] |
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| Name: | Gag-Pol polyprotein [489-587] |
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| Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 10781.16 |
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| Organism: | Human immunodeficiency virus type 1 |
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| Description: | P04585[489-587] |
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| Residue: | 99 |
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| Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
|
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|
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| BDBM50101482 |
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| n/a |
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| Name | BDBM50101482 |
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| Synonyms: | 3-(2-tert-Butyl-4-hydroxymethyl-5-methyl-phenylsulfanyl)-4-hydroxy-6-isopropyl-6-[2-(1H-pyrazol-3-yl)-ethyl]-5,6-dihydro-pyran-2-one | CHEMBL305814 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H34N2O4S |
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| Mol. Mass. | 458.613 |
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| SMILES | CC(C)C1(CCc2ccn[nH]2)CC(=O)C(Sc2cc(C)c(CO)cc2C(C)(C)C)C(=O)O1 |
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| Structure | 
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