Reaction Details |
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Target | 5-hydroxytryptamine receptor 1A |
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Ligand | BDBM50095830 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1419 (CHEMBL616207) |
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Ki | 3.4±n/a nM |
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Citation | López-Rodríguez, ML; Morcillo, MJ; Fernández, E; Rosado, ML; Pardo, L; Schaper, K Synthesis and structure-activity relationships of a new model of arylpiperazines. Study of the 5-HT(1a)/alpha(1)-adrenergic receptor affinity by classical hansch analysis, artificial neural networks, and computational simulation of ligand recognition. J Med Chem44:198-207 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 1A |
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Name: | 5-hydroxytryptamine receptor 1A |
Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46445.29 |
Organism: | Rattus norvegicus (rat) |
Description: | Binding assays were performed using rat hippocampal membranes. |
Residue: | 422 |
Sequence: | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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BDBM50095830 |
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n/a |
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Name | BDBM50095830 |
Synonyms: | 2-{4-[4-(2-Bromo-phenyl)-piperazin-1-yl]-butyl}-tetrahydro-imidazo[1,5-a]pyridine-1,3-dione | CHEMBL62694 |
Type | Small organic molecule |
Emp. Form. | C21H29BrN4O2 |
Mol. Mass. | 449.385 |
SMILES | Oc1c2CCCCn2c(=O)n1CCCCN1CCN(CC1)c1ccccc1Br |
Structure |
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