| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Endothelin-1 receptor |
|---|
| Ligand | BDBM50105052 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_65793 (CHEMBL677974) |
|---|
| IC50 | >10±n/a nM |
|---|
| Citation |  Morimoto, H; Ohashi, N; Shimadzu, H; Kushiyama, E; Kawanishi, H; Hosaka, T; Kawase, Y; Yasuda, K; Kikkawa, K; Yamauchi-Kohno, R; Yamada, K Potent and selective ET-A antagonists. 2. Discovery and evaluation of potent and water soluble N-(6-(2-(aryloxy)ethoxy)-4-pyrimidinyl)sulfonamide derivatives. J Med Chem44:3369-77 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Endothelin-1 receptor |
|---|
| Name: | Endothelin-1 receptor |
|---|
| Synonyms: | EDNRA | EDNRA_PIG | Endothelin receptor ET-A |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 48707.29 |
|---|
| Organism: | Sus scrofa |
|---|
| Description: | ChEMBL_65803 |
|---|
| Residue: | 427 |
|---|
| Sequence: | METFCFRVSFWVALLGCVISDNPESHSTNLSTHVDDFTTFRGTEFSLVVTTHRPTNLALP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFENHDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEEHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERS
SHKDSIN
|
|
|
|---|
| BDBM50105052 |
|---|
| n/a |
|---|
| Name | BDBM50105052 |
|---|
| Synonyms: | 2-{2-[6-(4-tert-Butyl-benzenesulfonylamino)-5-p-tolyl-pyrimidin-4-yloxy]-ethoxy}-pyrimidine-5-carboxylic acid. 0.6H2O | CHEMBL324613 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H29N5O6S |
|---|
| Mol. Mass. | 563.625 |
|---|
| SMILES | Cc1ccc(cc1)-c1c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)ncnc1OCCOc1ncc(cn1)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
