| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50105059 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_65793 (CHEMBL677974) |
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| IC50 | 1.4±n/a nM |
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| Citation |  Morimoto, H; Ohashi, N; Shimadzu, H; Kushiyama, E; Kawanishi, H; Hosaka, T; Kawase, Y; Yasuda, K; Kikkawa, K; Yamauchi-Kohno, R; Yamada, K Potent and selective ET-A antagonists. 2. Discovery and evaluation of potent and water soluble N-(6-(2-(aryloxy)ethoxy)-4-pyrimidinyl)sulfonamide derivatives. J Med Chem44:3369-77 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA | EDNRA_PIG | Endothelin receptor ET-A |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48707.29 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_65803 |
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| Residue: | 427 |
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| Sequence: | METFCFRVSFWVALLGCVISDNPESHSTNLSTHVDDFTTFRGTEFSLVVTTHRPTNLALP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFENHDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEEHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERS
SHKDSIN
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| BDBM50105059 |
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| n/a |
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| Name | BDBM50105059 |
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| Synonyms: | 2-(4-{6-[2-(5-Bromo-pyrimidin-2-yloxy)-ethoxy]-5-p-tolyl-pyrimidin-4-ylsulfamoyl}-phenyl)-2-methyl-propionic acid. CH2Cl2 | CHEMBL115147 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H26BrN5O6S |
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| Mol. Mass. | 628.494 |
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| SMILES | Cc1ccc(cc1)-c1c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C(O)=O)ncnc1OCCOc1ncc(Br)cn1 |
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| Structure | 
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