Ki Summary

Reaction Details

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Target

Adenosine receptor A3

Ligand

BDBM50106539

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_31710 (CHEMBL873053)

9.6±n/a nM

Citation

Jacobson, KA; Gao, ZG; Chen, A; Barak, D; Kim, SA; Lee, K; Link, A; Rompaey, PV; van Calenbergh, S; Liang, BT Neoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosides. J Med Chem44:4125-36 (2001) [PubMed]

More Info.:

Get all data from this article, Assay Method

Adenosine receptor A3

Name:

Adenosine receptor A3

Synonyms:

A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

36197.32

Organism:

Homo sapiens (Human)

Description:

P0DMS8

Residue:

318

Sequence:

MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIA
VGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKR
VTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYF
SFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFA
LSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKAC
VVCHPSDSLDTSIEKNSE

BDBM50106539

n/a

Name

BDBM50106539

Synonyms:

(2S,3S,4R,5R)-5-(6-Amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid (2-amino-ethyl)-amide | (2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-(2-aminoethyl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide | 5'-N-[(2-AMINO)ETHYL CARBOXAMIDO] ADENOSINE | 5-(6-Amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid (2-amino-ethyl)-amide | Adenosine analog, 1 | CHEMBL129903

Type

Small organic molecule

Emp. Form.

C12H17N7O4

Mol. Mass.

323.3079

SMILES

NCCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12

Structure