| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium-dependent dopamine transporter |
|---|
| Ligand | BDBM50096192 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_62464 (CHEMBL678930) |
|---|
| Ki | 148±n/a nM |
|---|
| Citation |  Newman, AH; Robarge, MJ; Howard, IM; Wittkopp, SL; George, C; Kopajtic, T; Izenwasser, S; Katz, JL Structure-activity relationships at monoamine transporters and muscarinic receptors for N-substituted-3alpha-(3'-chloro-, 4'-chloro-, and 4',4''-dichloro-substituted-diphenyl)methoxytropanes. J Med Chem44:633-40 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium-dependent dopamine transporter |
|---|
| Name: | Sodium-dependent dopamine transporter |
|---|
| Synonyms: | DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) |
|---|
| Type: | Multi-pass membrane protein |
|---|
| Mol. Mass.: | 68749.45 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | P23977 |
|---|
| Residue: | 619 |
|---|
| Sequence: | MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQER
ETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHC
NNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLT
ACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVD
FYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSG
FVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGID
SAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAG
TSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIV
TFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDH
QLVDRGEVRQFTLRHWLLL
|
|
|
|---|
| BDBM50096192 |
|---|
| n/a |
|---|
| Name | BDBM50096192 |
|---|
| Synonyms: | 3-[(4-Chloro-phenyl)-phenyl-methoxy]-8-(3-propyl-phenyl)-8-aza-bicyclo[3.2.1]octane; hydrochloride | CHEMBL553957 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H32ClNO |
|---|
| Mol. Mass. | 446.023 |
|---|
| SMILES | CCCc1cccc(c1)N1C2CCC1CC(C2)OC(c1ccccc1)c1ccc(Cl)cc1 |TLB:7:9:15.14.16:11.12,THB:17:15:9:11.12| |
|---|
| Structure | 
|
|---|
Search and Browse
