| Reaction Details |
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 | Report a problem with these data |
| Target | Gamma-aminobutyric acid type B receptor subunit 1 |
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| Ligand | BDBM50113822 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_68553 (CHEMBL676976) |
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| IC50 | >100000±n/a nM |
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| Citation |  Frølund, B; Jørgensen, AT; Tagmose, L; Stensbøl, TB; Vestergaard, HT; Engblom, C; Kristiansen, U; Sanchez, C; Krogsgaard-Larsen, P; Liljefors, T Novel class of potent 4-arylalkyl substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. J Med Chem45:2454-68 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Gamma-aminobutyric acid type B receptor subunit 1 |
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| Name: | Gamma-aminobutyric acid type B receptor subunit 1 |
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| Synonyms: | GABA B | GABA B receptor | GABA uptake | GABA-B receptor 1 | GABA-B-R1 | GABA-BR1 | GABABR1 | GABR1_RAT | Gabbr1 | Gb1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 111548.69 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Q9Z0U4 |
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| Residue: | 991 |
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| Sequence: | MLLLLLVPLFLRPLGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDY
EIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPA
LDGARVEFRCDPDFHLVGSSRSVCSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGG
WPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKII
LMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLF
EKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARI
IVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKTYDPSINCTVEEMTEAVEG
HITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALAL
NKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQ
LQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSL
GIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRSQFPF
VCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMD
VLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSKKMNTWLGELWSFAVSSD
VQRRATVGGDSPICVWPAPESIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIY
NVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSET
QDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPT
PPDPSGGLPRGPSEPPDRLSCDGSRVHLLYK
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| BDBM50113822 |
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| n/a |
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| Name | BDBM50113822 |
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| Synonyms: | 5-(4-Methyl-piperidin-4-yl)-isoxazol-3-ol; hydrobromide | CHEMBL543840 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H14N2O2 |
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| Mol. Mass. | 182.2197 |
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| SMILES | CC1(CCNCC1)c1cc(=O)[nH]o1 |
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| Structure | 
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