| Reaction Details |
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 | Report a problem with these data |
| Target | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 |
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| Ligand | BDBM50116419 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_205054 (CHEMBL810248) |
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| IC50 | 3000±n/a nM |
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| Citation |  Picard, F; Barassin, S; Mokhtarian, A; Hartmann, RW Synthesis and evaluation of 2'-substituted 4-(4'-carboxy- or 4'-carboxymethylbenzylidene)-N-acylpiperidines: highly potent and in vivo active steroid 5alpha-reductase type 2 inhibitors. J Med Chem45:3406-17 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| 3-oxo-5-alpha-steroid 4-dehydrogenase 2 |
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| Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 |
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| Synonyms: | S5A2_RAT | Srd5a2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 28784.15 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_205054 |
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| Residue: | 254 |
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| Sequence: | MQIVCHQVPVLAGSATLATMGTLILCLGKPASYGKHTESVSSGVPFLPARIAWFLQELPS
FVVSVGMLAWQPRSLFGPPGNVLLALFSAHYFHRTFIYSLLTRGRPFPAVLFLRATAFCI
GNGLLQAYYLVYCAEYPEEWYTDVRFSFGVFLFILGMGINIHSDYTLRQLRKPGEVIYRI
PRGGLFTYVSGANFLGEIIEWIGYALATWSVPAFAFAFFTLCFLGMQAFYHHRFYLKMFK
DYPKSRKALIPFIF
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| BDBM50116419 |
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| n/a |
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| Name | BDBM50116419 |
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| Synonyms: | 4-[1-(2,2-Dicyclohexyl-acetyl)-piperidin-4-ylidenemethyl]-3-fluoro-benzoic acid | CHEMBL117793 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H36FNO3 |
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| Mol. Mass. | 441.578 |
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| SMILES | [#8]-[#6](=O)-c1ccc(\[#6]=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6](-[#6]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)-[#6]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)c(F)c1 |
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| Structure | 
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