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TargetCorticotropin-releasing factor receptor 1
LigandBDBM50119607
Substrate/Competitorn/a
Meas. Tech.ChEMBL_50974 (CHEMBL666692)
IC50 0.990000±n/a nM
Citation Rivier, J; Gulyas, J; Kirby, D; Low, W; Perrin, MH; Kunitake, K; DiGruccio, M; Vaughan, J; Reubi, JC; Waser, B; Koerber, SC; Martinez, V; Wang, L; Taché, Y; Vale, W Potent and long-acting corticotropin releasing factor (CRF) receptor 2 selective peptide competitive antagonists. J Med Chem45:4737-47 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Corticotropin-releasing factor receptor 1
Name:Corticotropin-releasing factor receptor 1
Synonyms:CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:Enzyme
Mol. Mass.:50744.31
Organism:Homo sapiens (Human)
Description:P34998
Residue:444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLR
NIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGC
YLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYI
YQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFF
VNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARV
ARAMSIPTSPTRVSFHSIKQSTAV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50119607
n/a
NameBDBM50119607
Synonyms:CHEMBL440057 | E G P P I S I D L S L E L L R K M I E I E K Q E K E K Q Q A A N N R L L L D T I I-NH2(r/h CRF) | Human corticotropin releasing factor
TypeSmall organic molecule
Emp. Form.C208H343N59O64S2
Mol. Mass.4758.436
SMILESn/a
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: