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TargetCorticotropin-releasing factor receptor 1
LigandBDBM50119607
Substrate/Competitorn/a
Meas. Tech.ChEMBL_51127 (CHEMBL663562)
IC50 12±n/a nM
Citation Rivier, J; Gulyas, J; Kirby, D; Low, W; Perrin, MH; Kunitake, K; DiGruccio, M; Vaughan, J; Reubi, JC; Waser, B; Koerber, SC; Martinez, V; Wang, L; Taché, Y; Vale, W Potent and long-acting corticotropin releasing factor (CRF) receptor 2 selective peptide competitive antagonists. J Med Chem45:4737-47 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Corticotropin-releasing factor receptor 1
Name:Corticotropin-releasing factor receptor 1
Synonyms:CRF-R | CRF1 | CRFR1_RAT | CRH-R 1 | Corticotropin releasing factor receptor | Corticotropin releasing factor receptor 1 | Corticotropin-releasing Factor Receptor 1 | Corticotropin-releasing hormone receptor 1 | Crhr | Crhr1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:47870.75
Organism:Rattus norvegicus (rat)
Description:Receptor binding assays were performed using rat cortex homogenate.
Residue:415
Sequence:
MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEV
HQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPF
PIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA
STTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVS
VFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
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  Blast E-value cutoff:
BDBM50119607
n/a
NameBDBM50119607
Synonyms:CHEMBL440057 | E G P P I S I D L S L E L L R K M I E I E K Q E K E K Q Q A A N N R L L L D T I I-NH2(r/h CRF) | Human corticotropin releasing factor
TypeSmall organic molecule
Emp. Form.C208H343N59O64S2
Mol. Mass.4758.436
SMILESn/a
Structure
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