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TargetHuman immunodeficiency virus type 1 protease
LigandBDBM845
Substrate/Competitorn/a
Meas. Tech.ChEMBL_158026
Ki 0.3±n/a nM
Kd 21±n/a nM
KON 889000 M-1s-1
Citation Markgren POSchaal WHämäläinen MKarlén AHallberg ASamuelsson BDanielson UH Relationships between structure and interaction kinetics for HIV-1 protease inhibitors. J Med Chem 45:5430-9 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Human immunodeficiency virus type 1 protease
Name:Human immunodeficiency virus type 1 protease
Synonyms:Pol polyprotein
Type:Enzyme Subunit
Mol. Mass.:10781.16
Organism:Human immunodeficiency virus type 1
Description:n/a
Residue:99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM845
n/a
NameBDBM845
Synonyms:(2R,3R,4R,5R)-2,5-bis[(4-bromophenyl)methoxy]-3,4-dihydroxy-N,N'-bis[(1S)-2-methyl-1-(methylcarbamoyl)propyl]hexanediamide | C2-Symmetric inhibitor 3 | CHEMBL124139 | N1, N6-Bis[(1S)-2-methyl-1-(methylcarbamoyl)propyl]-(2R,3R,4R,5R)-2,5-bis(4-bromobenzyloxy)-3,4-dihydroxy-hexanediamide
TypeSmall organic molecule
Emp. Form.C32H44Br2N4O8
Mol. Mass.772.522
SMILESCNC(=O)[C@@H](NC(=O)[C@H](OCc1ccc(Br)cc1)[C@H](O)[C@@H](O)[C@@H](OCc1ccc(Br)cc1)C(=O)N[C@@H](C(C)C)C(=O)NC)C(C)C |r|
Structure
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