| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-3 adrenergic receptor |
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| Ligand | BDBM50122649 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_38644 (CHEMBL652588) |
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| EC50 | 7.4±n/a nM |
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| Citation |  Tanaka, N; Tamai, T; Mukaiyama, H; Hirabayashi, A; Muranaka, H; Ishikawa, T; Kobayashi, J; Akahane, S; Akahane, M Relationship between stereochemistry and the beta3-adrenoceptor agonistic activity of 4'-hydroxynorephedrine derivative as an agent for treatment of frequent urination and urinary incontinence. J Med Chem46:105-12 (2002) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-3 adrenergic receptor |
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| Name: | Beta-3 adrenergic receptor |
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| Synonyms: | ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 43534.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 408 |
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| Sequence: | MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV
AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC
VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV
GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG
ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT
FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL
CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
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| BDBM50122649 |
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| n/a |
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| Name | BDBM50122649 |
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| Synonyms: | (2-Chloro-4-{2-[2-hydroxy-2-(4-hydroxy-phenyl)-1-methyl-ethylamino]-ethyl}-phenoxy)-acetic acid ethyl ester; hydrochloride | CHEMBL544427 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H26ClNO5 |
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| Mol. Mass. | 407.888 |
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| SMILES | CCOC(=O)COc1ccc(CCNC(C)C(O)c2ccc(O)cc2)cc1Cl |
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| Structure | 
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